This preparation is available in the form of a sterile dry powder containing benzyl penicillin sodium and procaine penicillin with suitable amount of suspending and buffering agents. The advantage of such a preparation is that it can exert both the prompt action due to the high initial blood levels produced by the soluble potassium salt, and the prolonged action of the insoluble procaine penicillin salt, which is absorbed and excreted slowly.
Therefore a single dose injection of this preparation can maintain an effective concentration in blood for 12-24 hours.
It has the same indications as penicillin. As its peak blood concentration is relatively low, it is only indicated in mild infections caused by penicillin-sensitive bacteria, such as tonsillitis, scarlet fever, erysipelas, furuncles and carbuncles. It is also effective for syphilis, Vincent's angina and gonorrhea.
DOSAGE AND ADMINISTRATION:
It is given by I.M. injection only.
A suitable amount of water for injection is added into the vial before use. 500,000 IU-1,000,000 IU each time, once or twice a day.
Before administration, skin tests of procaine and penicillin should be made. It should not be administrated to patients hypersensitive to penicillin and procaine.
Kept in well-closed containers and stored in a dry place
RECOMMENDED SHELF LIFE:
In vials of 4,000,000 IU-each containing 3,000,000 IU of procaine penicillin and l,000,000 IU of penicillin sodium.
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